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Causes of Type 1 Diabetes

Type 1 diabetes belongs to a group of conditions known as autoimmune diseases. Autoimmune diseases are when the body incorrectly identifies its own useful cells as an attacking organism.

In type 1 diabetes, it is the beta cells in the pancreas which produce insulin that are wrongfully targeted and killed off by specific antibodies created by the body’s immune system.

Researchers have been investigating what may cause the immune system to act in this way but to date researchers have theories but no concrete proof.

Genetic predisposition

Researchers have uncovered a number of genetic regions that are linked closely with type 1 diabetes. Each of these is denoted with a name such as IDDM1.

At least 18 different regions have been discovered and some of the genetic areas include an increased susceptibility for other autoimmune diseases such as rheumatoid arthritis and coeliac disease.

Whilst genetics offers clues as to why some people are more susceptible to type 1 diabetes, it doesn’t explain why some people with these genes develop type 1 diabetes and why others with these genes don’t.

For example, having an identical twin with type 1 diabetes gives you a statistically higher risk but it doesn’t necessarily mean you will develop the condition.

Genetics does not explain either why people will develop type 1 diabetes at different ages. Type 1 diabetes is most commonly diagnosed in 10 to 14 year olds but can be diagnosed at any age.

  • Read more on diabetes and genetics

Type 1 diabetes triggers

Researchers have hypothesised that whilst some people are have a genetic predisposition to type 1 diabetes, there is likely to be an environmental factor that triggers the initial development of type 1 diabetes.

Some of the possible triggers that have been suggested include:

  • Viral infection
  • Vaccines
  • Low levels of vitamin D
  • Cow’s milk
  • Increased insulin demand

Viral infection

Associations have been found between type 1 diabetes and a number of different viruses. Of these, enteroviruses have attracted the most interest from researchers. Studies have shown that enterovirus antibodies have been recorded at higher levels in pregnant mothers of children that gone on to develop type 1 diabetes. Higher frequencies of enterovirus infections have also been detected in children which develop type 1 diabetes when compared with siblings that have not developed the condition.

Vaccinations

Another theory put forward is that childhood vaccinations could increase the chances of developing type 1 diabetes. One researcher, Dr J B Classen has investigated incidences of type 1 diabetes in the human population as well as in animals. Dr Classen’s research indicates there could be a link between type 1 diabetes and childhood vaccinations such as smallpox, tuberculosis and Hib vaccines.

The research has yet to be accepted as conclusive enough to change vaccination schedules.

An interesting note about the tuberculosis vaccine, also known as the BCG vaccine, is that in addition to being linked with greater incidence of type 1 diabetes, it has also been shown to have uses as a vaccination against type 1 diabetes.

 

Courtesy: Mayo Clinic
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